A thiamine antimetabolite; converted by thiamine pyrophosphokinase to oxythiamine pyrophosphate; decreases transketolase activity in and is cytotoxic to MDA-MB-231 breast cancer cells at 5 mM; inhibits the nonoxidative synthesis of ribose and decreases RNA and DNA synthesis in MIA PaCa-2 pancreatic cancer cells at 0.5 µM; induces cell cycle arrest at the G0/G1 phase and apoptosis in an Ehrlich murine spontaneous adenocarcinoma model; reduces tumor growth in an SMMC mouse xenograft model in combination with sorafenib; has been used to induce thiamine deficiency in mice

Oxythiamine (chloride hydrochloride) – 25 g

Brand:
Cayman
CAS:
614-05-1
Storage:
-20
UN-No:
Non-Hazardous - /

Oxythiamine is a thiamine antimetabolite that has anticancer activities.{55009,55010,48952} It is converted by thiamine pyrophosphokinase to oxythiamine pyrophosphate, a transketolase inhibitor.{55009} Oxythiamine (5 mM) decreases transketolase activity in and is cytotoxic to MDA-MB-231 breast cancer cells.{48955} It inhibits the nonoxidative synthesis of ribose and decreases RNA and DNA synthesis in MIA PaCa-2 pancreatic cancer cells when used at a concentration of 0.5 µM.{55010} In vivo, oxythiamine (400 and 500 mg/kg per day) induces cell cycle arrest at the G1 phase and apoptosis in an Ehrlich murine spontaneous adenocarcinoma model.{48952} Oxythiamine, in combination with sorafenib, reduces tumor growth in an SMMC mouse xenograft model.{48953} It has also been used to induce thiamine deficiency in mice.{48954}  

 

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SKU: 29953 - 25 g Category:

Description

A thiamine antimetabolite; converted by thiamine pyrophosphokinase to oxythiamine pyrophosphate; decreases transketolase activity in and is cytotoxic to MDA-MB-231 breast cancer cells at 5 mM; inhibits the nonoxidative synthesis of ribose and decreases RNA and DNA synthesis in MIA PaCa-2 pancreatic cancer cells at 0.5 µM; induces cell cycle arrest at the G0/G1 phase and apoptosis in an Ehrlich murine spontaneous adenocarcinoma model; reduces tumor growth in an SMMC mouse xenograft model in combination with sorafenib; has been used to induce thiamine deficiency in mice

Formal name: 3-[(1,6-dihydro-2-methyl-6-oxo-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-thiazolium, monochloride, monohydrochloride

Synonyms: 

Molecular weight: 338.3

CAS: 614-05-1

Purity: ≥95%

Formulation: A solid

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