A muscarinic acetylcholine receptor antagonist (Kds = 0.11 and 0.17 nM for guinea pig atria and ileum

Oxyphenonium (bromide) – 1 g

Brand:
Cayman
CAS:
50-10-2
Storage:
-20
UN-No:
Non-Hazardous - /

Oxyphenonium is an antagonist of muscarinic acetylcholine receptors that binds to muscarinic receptors on isolated guinea pig atria and ileum (Kds = 0.11 and 0.17 nM, respectively).{36510} In vivo, oxyphenonium reverses carbaminocholine- and acetylcholine-induced decreases in blood pressure in anesthetized cats (ED50s = 0.591 and 1 μg/kg, respectively).{36511} It decreases rumenal ulcer formation in rats and suppresses insulin-induced gastric secretion in dogs with gastric fistulas.{36512} Oxyphenonium also prevents form-deprivation myopia (FDM) in a chick model of experimental myopia.{36513} Formulations containing oxyphenonium have been used to treat peptic ulcers.  

 

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SKU: 23880 - 1 g Category:

Description

A muscarinic acetylcholine receptor antagonist (Kds = 0.11 and 0.17 nM for guinea pig atria and ileum, respectively); reverses carbaminocholine- and acetylcholine-induced decreases in blood pressure in anesthetized cats (ED50s = 0.591 and 1 μg/kg, respectively); decreases rumenal ulcer formation in rats and suppresses insulin-induced gastric secretion in dogs with gastric fistulas; prevents FDM in a chick model of experimental myopia

Formal name: 2-[(2-cyclohexyl-2-hydroxy-2-phenylacetyl)oxy]-N,N-diethyl-N-methyl-ethanaminium, monobromide

Synonyms:  (±)-Oxyphenonium

Molecular weight: 428.4

CAS: 50-10-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypotension||Research Area|Neuroscience|Ophthalmology

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