An NSAID that reduces edema in certain types of acute inflammation in animal models; a poor inhibitor of prostaglandin synthesis

Oxyphenbutazone – 1 mg

Brand:
Cayman
CAS:
129-20-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Oxyphenbutazone is a metabolite of phenylbutazone (Item No. 70400). Both compounds were identified as having anti-inflammatory effects in early studies, and, as a result, are considered NSAIDs.{30271} Interestingly, the effects of the two compounds in animal models differ, with phenylbutazone having anti-inflammatory effects in rheumatic diseases and oxyphenbutazone reducing edema in certain types of acute inflammation.{30271} Oxyphenbutazone is a poor inhibitor of prostaglandin synthesis, but, like other NSAIDs, it inhibits organic anion transporter 1 (Ki = 32 µM).{30270,30268} It inhibits the growth of MH60/BSF-2 cells induced by IL-6 (IC50 = 7.5 µM).{29361} Oxyphenbutazone stimulates neurite outgrowth at 1.5 µM and sensitizes M. tuberculosis to antimicrobials.{30272,30269}  

 

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Description

An NSAID that reduces edema in certain types of acute inflammation in animal models; a poor inhibitor of prostaglandin synthesis, but, like other NSAIDs, it inhibits OAT1 (Ki = 32 µM)

Formal name: 4-butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione

Synonyms:  p-Hydroxyphenylbutazone|G 27202|NSC 526053|Ro 04-4410

Molecular weight: 324.4

CAS: 129-20-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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