Description
An antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40 nM for human recombinant M1-5, respectively); inhibits carbachol- induced intracellular calcium mobilization in bladder smooth muscle and submandibular gland cells isolated from cynomolgus monkeys (Kis = 2 and 1 nM, respectively); inhibits VIBC and OIS in rats (ID50s = 0.062 and 0.089 mg/kg, respectively); increases PD and LMA (ED50s = 0.29 and 0.52 mg/kg, respectively) and decreases SIT (ID50 = 0.22 mg/kg) in rats
Formal name: 4-(diethylamino)-2-butyn-1-yl ester α-cyclohexyl-α-hydroxy-benzeneacetic acid, monohydrochloride
Synonyms: MJ4309-1
Molecular weight: 394
CAS: 1508-65-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Ophthalmology
