A uricase inhibitor; induces embryotoxicity and nephrotoxicity in rats; a component of S-1

Oxonic Acid (potassium salt) – 5 g

Brand:
Cayman
CAS:
2207-75-2
Storage:
-20
UN-No:
Non-Hazardous - /

Oxonic acid is a uricase inhibitor that prevents metabolism and excretion of uric acid (Item No. 16219) and induces embryotoxicity and nephrotoxicity in rats.{40118} It is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil (5-FU; Item No. 14416), that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats.{40119} Formulations containing oxonic acid have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas.{40120}  

 

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Description

A uricase inhibitor; induces embryotoxicity and nephrotoxicity in rats; a component of S-1, a mixture containing a prodrug of the antitumor agent 5-FU, that suppresses the GI toxicity of 5-FU without inhibiting its antitumor activity in rats

Formal name: 1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazine-2-carboxylic acid, monopotassium salt

Synonyms:  Allantoxanic Acid|Potassium oxonate

Molecular weight: 195.2

CAS: 2207-75-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer

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