A quinolone antibiotic that inhibits bacterial DNA gyrase

Oxolinic Acid – 1 g

Brand:
Cayman
CAS:
14698-29-4
Storage:
-20
UN-No:
Non-Hazardous - /

Bacterial DNA gyrase is a heterodimeric type II topoisomerase that negatively supercoils circular double-stranded DNA.{22833,27399} Oxolinic acid is a quinolone antibiotic that inhibits bacterial DNA gyrase, but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 µg/ml.{22833,27401,27400} Oxolinic acid also blocks neuronal uptake of dopamine in mammals (IC50 = 4.3 µM), leading to an increase in locomotor activity.{27402}  

 

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Description

A quinolone antibiotic that inhibits bacterial DNA gyrase, but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes , blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 µg/ml; also blocks neuronal uptake of dopamine in mammals (IC50 = 4.3 µM)

Formal name: 5-ethyl-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid

Synonyms:  NSC 110364|Urinox

Molecular weight: 261.2

CAS: 14698-29-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Neuroscience

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