A non-steroidal anti-inflammatory drug that inhibits COX-1 (IC50 = 2.2 μM) and COX-2 (IC50 = 36 μM) in human synovial cells; inhibits TXB2 production in human platelets (IC50 = ~2 μM) and PGE2 production by human synovial cells (IC50 = ~20 μM)

Oxaprozin – 5 mg

Brand:
Cayman
CAS:
21256-18-8
Storage:
-20
UN-No:
Non-Hazardous - /

Oxaprozin is a non-steroidal anti-inflammatory drug that inhibits COX-1 and COX-2 in human synovial cells with IC50 values of 2.2 and 36 μM, respectively.{23288} It has been reported to inhibit thromboxane B2 (Item No. 19030) production in human platelets (IC50 = ~2 μM) and to inhibit prostaglandin E2 (Item No. 14010) production by human synovial cells stimulated with IL-1β (IC50 = ~20 μM).{23288} It demonstrates analgesic and anti-inflammatory activity in rodent models at doses of 70-100 mg/kg.{25154}  

 

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Description

A non-steroidal anti-inflammatory drug that inhibits COX-1 (IC50 = 2.2 μM) and COX-2 (IC50 = 36 μM) in human synovial cells; inhibits TXB2 production in human platelets (IC50 = ~2 μM) and PGE2 production by human synovial cells (IC50 = ~20 μM)

Formal name: 4,5-diphenyl-2-oxazolepropanoic acid

Synonyms:  Daypro|NSC 310839|Wy 21743

Molecular weight: 293.3

CAS: 21256-18-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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