A platinum-based antineoplastic agent that forms DNA adducts specifically in cancer cells

Oxaliplatin – 250 mg

Brand:
Cayman
CAS:
61825-94-3
Storage:
-20
UN-No:
Non-Hazardous - /

Oxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death.{21805,21804} Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively.{21804} Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.{21805,21806}  

 

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Description

A platinum-based antineoplastic agent that forms DNA adducts specifically in cancer cells, preventing DNA replication and transcription which induces apoptosis; cytotoxic in colon, ovarian, and lung cancer cell lines (IC50s = 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively)

Formal name: (SP-4-2)-[1R,2R-cyclohexanediamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]-platinum

Synonyms:  Dacplat|Eloxatin™|Elplat|Lipoxal|NSC 266046|RP 54780

Molecular weight: 397.3

CAS: 61825-94-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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