A semisynthetic β-lactam antibiotic; active against clinical isolates of methicillin-susceptible S. aureus and penicillin-susceptible S. pneumoniae

Oxacillin (sodium salt) – 5 g

Brand:
Cayman
CAS:
1173-88-2
Storage:
-20
UN-No:
Non-Hazardous - /

Oxacillin is a semisynthetic β-lactam antibiotic.{32140,39735} It is active against clinical isolates of methicillin-susceptible S. aureus and penicillin-susceptible S. pneumoniae, as well as group A, group B, and viridans group streptococci with MIC90 values ranging from 0.06 to 2 µg/ml in vitro.{22658} Oxacillin is less effective toward other bacteria with MIC90 values of greater than 16 µg/ml for S. epidermidis, S. haemolyticus, E. faecalis, E. faecium, methicillin-resistant S. aureus (MRSA), and penicillin-intermediate and -resistant S. pneumoniae. It targets the bacterial cell wall, inhibiting S. pneumoniae penicillin-binding proteins 1a, 1b, 2a, 2b, and 3 in vitro with IC50 values ranging from 0.17 to 1.75 µM.{21711,39735} Oxacillin inhibits growth of S. aureus in a thigh model of infection in mice (ED50 = 45.19 mg/kg, s.c.).{39736} Formulations containing oxacillin have been used in the treatment of susceptible bacterial infections.  

 

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SKU: 23954 - 5 g Category:

Description

A semisynthetic β-lactam antibiotic; active against clinical isolates of methicillin-susceptible S. aureus and penicillin-susceptible S. pneumoniae, as well as group A, group B, and viridans group streptococci in vitro (MIC90s = 0.06-2 µg/ml); less effective toward other bacteria (MIC90 = >16 µg/ml for S. epidermidis, S. haemolyticus, E. faecalis, E. faecium, MRSA, and penicillin-intermediate and -resistant S. pneumoniae); targets the bacterial cell wall; inhibits S. pneumoniae penicillin-binding proteins 1a, 1b, 2a, 2b, and 3 in vitro (IC50s = 0.17-1.75 µM); inhibits growth of S. aureus in a thigh model of infection in mice (ED50 = 45.19 mg/kg, s.c.)

Formal name: (2S,5R,6R)-3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt

Synonyms:  Micropenin|NSC 527712|SQ16423

Molecular weight: 423.4

CAS: 1173-88-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Penicillins||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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