A dual inhibitor of mTORC1 and mTORC2 (IC50s = 11 and 29 nM

OXA-01 – 10 mg

Brand:
Cayman
CAS:
936889-68-8
Storage:
-20
UN-No:
Non-Hazardous - /

OXA-01 is an inhibitor of both mTORC1 and mTORC2 (IC50s = 11 and 29 nM, respectively).{29741} It is selective for mTOR over PI3K isoforms and DNA protein kinase.{29741} OXA-01 reduces VEGF production in tumors in association with decreased vessel sprouting.{29741}  

 

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Description

A dual inhibitor of mTORC1 and mTORC2 (IC50s = 11 and 29 nM, respectively); reduces VEGF production in tumors in association with decreased vessel sprouting

Formal name: trans-4-[8-amino-1-(7-chloro-1H-indol-2-yl)imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid

Synonyms: 

Molecular weight: 409.9

CAS: 936889-68-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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