An inhibitor of TOPK (IC50 = 28 nM); specifically blocks cytokinesis

OTS964 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
1338545-07-5
Storage:
-20
UN-No:
Non-Hazardous - /

OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM).{32494} It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells.{32494,32493} OTS964 induces apoptosis of human lung cancer cells in mouse xenografts.{32494}  

 

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Description

An inhibitor of TOPK (IC50 = 28 nM); specifically blocks cytokinesis, leading to apoptosis, in cancer cells in vitro and in mice

Formal name: 9-[4-[(1R)-2-(dimethylamino)-1-methylethyl]phenyl]-8-hydroxy-6-methyl-thieno[2,3-c]quinolin-4(5H)-one, monohydrochloride

Synonyms: 

Molecular weight: 429

CAS: 1338545-07-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling

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