A saponin with antiviral and anticancer activities; an inhibitor of OSBP and its paralog ORP4 (Kis = 16 and 71 nM in radioligand binding assays using HEK293T cell lysates); inhibits replication of a variety of enteroviruses (IC50s = 2.4-9.4 nM); inhibits replication of CVB3 in infected HeLa R19 cells in an OSBP-dependent manner at 3 nM; protects against CVA9 and echovirus 2 infection in HeLa cells at 10 nM; inhibits replication of HCV but not MHV

OSW-1 – 5 mg

Brand:
Cayman
CAS:
145075-81-6
Storage:
-20
UN-No:
Non-Hazardous - /

OSW-1 is a saponin that has been found in O. saundersiae and has antiviral and anticancer activities.{53441} It is an inhibitor of oxysterol-binding protein (OSBP) and its paralog OSBP-related protein 4 (ORP4) with Ki values of 16 and 71 nM, respectively, in radioligand binding assays using HEK293T cell lysates.{53442} It induces OSBP translocalization from the cytoplasm to the trans-Golgi network and decreases intracellular levels of OSBP in HEK293 cells.{53442,45822} OSW-1 inhibits replication of a variety of enteroviruses (IC50s = 2.4-9.4 nM), including replication of coxsackievirus B3 (CVB3) in infected HeLa R19 cells in an OSBP-dependent manner when used at a concentration of 3 nM.{53443} It also inhibits replication of hepatitis C virus (HCV) but not mouse hepatitis virus (MHV), a coronavirus.{45895} It protects against CVA9 and echovirus 2 infection in HeLa cells when used at a concentration of 10 nM.{53443} OSW-1 inhibits growth of HeLa and HEK293 cells (GI50s = 0.33 and 0.22 nM, respectively).{53442}  

 

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SKU: 30310 - 5 mg Category:

Description

A saponin with antiviral and anticancer activities; an inhibitor of OSBP and its paralog ORP4 (Kis = 16 and 71 nM in radioligand binding assays using HEK293T cell lysates); inhibits replication of a variety of enteroviruses (IC50s = 2.4-9.4 nM); inhibits replication of CVB3 in infected HeLa R19 cells in an OSBP-dependent manner at 3 nM; protects against CVA9 and echovirus 2 infection in HeLa cells at 10 nM; inhibits replication of HCV but not MHV, a coronavirus; inhibits growth of HeLa and HEK293 cells (GI50s = 0.33 and 0.22 nM, respectively)

Formal name: (3β,16β)-16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxy-cholest-5-en-22-one

Synonyms:  Orsaponin

Molecular weight: 873

CAS: 145075-81-6

Purity: ≥95%

Formulation: A crystalline solid

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