A coumarin with diverse biological activities; decreases secretion of HBsAg from Huh7 cells transfected with HBV DNA by 70% at 20 µg/ml; induces BMP2 production in and differentiation of MG-63 and hFOB osteoblast-like cells; induces vasorelaxation in isolated rat blood vessels

Osthole – 250 mg

Brand:
Cayman
CAS:
484-12-8
Storage:
-20
UN-No:
Non-Hazardous - /

Osthole is a coumarin that has been found in C. monnieri and has diverse biological activities.{31047,31048,31049} It decreases secretion of hepatitis B surface antigen (HBsAg) from Huh7 cells transfected with hepatitis B virus (HBV) DNA by 70% when used at a concentration of 20 µg/ml.{31047} Osthole induces bone morphogenetic protein 2 (BMP2) production in and differentiation of MG-63 and hFOB osteoblast-like cells.{31048} It induces vasorelaxation in isolated rat blood vessels, ileum, corpus cavernosum, and trachea.{31049} Osthole inhibits migration and invasion of MCF-7, MDA-MB-231, H1299, and A549 cancer cells in vitro and increases survival in an SMMC-7721 hepatocellular carcinoma mouse xenograft model. It also has hepatoprotective effects in mouse models of hepatitis induced by concanavalin A (Item No. 14951) and alcoholic fatty liver disease.  

 

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Description

A coumarin with diverse biological activities; decreases secretion of HBsAg from Huh7 cells transfected with HBV DNA by 70% at 20 µg/ml; induces BMP2 production in and differentiation of MG-63 and hFOB osteoblast-like cells; induces vasorelaxation in isolated rat blood vessels, ileum, corpus cavernosum, and trachea; inhibits migration and invasion of MCF-7, MDA-MB-231, H1299, and A549 cancer cells in vitro; increases survival in an SMMC-7721 hepatocellular carcinoma mouse xenograft model; hepatoprotective in mouse models of concanavalin A-induced hepatitis and alcoholic fatty liver disease

Formal name: 7-methoxy-8-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-2-one

Synonyms:  7-Methoxy-8-(3-methyl-2-butenyl)coumarin|NSC 31868

Molecular weight: 244.3

CAS: 484-12-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Coumarins||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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