A SIRT6 inhibitor (IC50 = 89 μM); selective for SIRT6 over SIRT1 and 2 (IC50s = 1

OSS-128167 – 1 mg

Brand:
Cayman
CAS:
887686-02-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

OSS-128167 is an inhibitor of sirtuin 6 (SIRT6; IC50 = 89 μM).{45584} It is selective for SIRT6 over SIRT1 and SIRT2 (IC50s = 1,578 and 751 μM, respectively). OSS-128167 increases acetylation of histone H3 lysine 9 (H3K9) and glucose uptake and decreases TNF-α release in BxPC-3 cells. In vivo, OSS-128167 (100 μg/animal, i.c.v.) prevents decreases in left hemisphere cerebral levels of IL-1β, TNF-α, and IL-6 and neutrophil infiltration induced by bexarotene (Item No. 11571) in a rat model of subarachnoid hemorrhage.{45585}  

 

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SKU: 29052 - 1 mg Category:

Description

A SIRT6 inhibitor (IC50 = 89 μM); selective for SIRT6 over SIRT1 and 2 (IC50s = 1,578 and 751 μM, respectively); increases H3K9 acetylation and glucose uptake and decreases TNF-α release in BxPC-3 cells; prevents bexarotene-induced decreases in left hemisphere cerebral levels of IL-1β, TNF-α, and IL-6 and neutrophil infiltration in a rat model of subarachnoid hemorrhage at 100 μg/animal, i.c.v.

Formal name: 5-[[3-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-benzoic acid

Synonyms: 

Molecular weight: 366.3

CAS: 887686-02-4

Purity: ≥98%

Formulation: A crystalline solid

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