A SERM; binds to ERα and ERβ (Kis = 380 and 410 nM

Ospemifene – 250 mg

Brand:
Cayman
CAS:
128607-22-7
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM) that binds to the estrogen receptors ERα and ERβ (Kis = 380 and 410 nM, respectively).{41365} It increases vaginal weight and vaginal epithelial height (ED50s = 0.48 and 0.39 mg/kg per day, respectively) in an ovariectomized rat model of menopause. Ospemifene also upregulates progesterone receptors in vaginal epithelium and stroma and inhibits estrogen response element-induced transactivation in MCF-7 cells. Formulations containing ospemifene have been used to treat vulvar and vaginal atrophy-induced dyspareunia.  

 

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SKU: 23755 - 250 mg Category:

Description

A SERM; binds to ERα and ERβ (Kis = 380 and 410 nM, respectively); increases vaginal weight and vaginal epithelial height (ED50s = 0.48 and 0.39 mg/kg per day, respectively) in an ovariectomized rat model of menopause; upregulates progesterone receptors in vaginal epithelium and stroma; inhibits estrogen response element-induced transactivation in MCF-7 cells

Formal name: 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-ethanol

Synonyms:  FC-1271a

Molecular weight: 378.9

CAS: 128607-22-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Reproductive Biology

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