An OGT inhibitor (IC50 = 2.7 μM); inhibits global O-GlcNAcylation in a dose-dependent manner in CHO cells; induces a mass shift of Nup62 that corresponds to the loss of O-GlcNAc residues; decreases levels of cellular OGA; causes a 50% decrease in CHO cell viability after 24 hours

OSMI-1 – 5 mg

Brand:
Cayman
CAS:
1681056-61-0
Storage:
-20
UN-No:
Non-Hazardous - /

OSMI-1 is a quinolinone-6-sulfonamide that inhibits O-GlcNAc transferase (OGT; IC50 = 2.7 μM) in vitro.{39059} It is cell permeable and inhibits global O-GlcNAcylation in a dose-dependent manner in CHO cells. OSMI-1 induces a mass shift of nucleoporin62 (Nup62) that corresponds to the loss of O-GlcNAc residues and decreases levels of cellular O-GlcNAcase (OGA). OSMI-1 (50 μM) also causes a 50% decrease in CHO cell viability after 24 hours.  

 

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Description

An OGT inhibitor (IC50 = 2.7 μM); inhibits global O-GlcNAcylation in a dose-dependent manner in CHO cells; induces a mass shift of Nup62 that corresponds to the loss of O-GlcNAc residues; decreases levels of cellular OGA; causes a 50% decrease in CHO cell viability after 24 hours ,

Formal name: αR-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-benzeneacetamide

Synonyms: 

Molecular weight: 563.6

CAS: 1681056-61-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acyltransferases||Research Area

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