A muscarinic acetylcholine receptor antagonist (Kds = 48

Orphenadrine (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
341-69-5
Storage:
-20
UN-No:
- 2811 / 6.1

Orphenadrine is a muscarinic acetylcholine receptor (mAChR) antagonist (Kds = 48, 213, 120, 170, and 129 nM for M1-M5 receptors, respectively).{25806} Orphenadrine (2-5 mg/kg, i.v.) decreases muscle activity induced by the mAChR agonist oxotremorine in rabbits.{47476} It is also an NMDA receptor antagonist with a Ki value of 6 µM in a radioligand binding assay in human postmortem frontal cortex and an IC50 value of 16.2 µM for inhibiting steady state currents in cultured superior colliculus neurons.{47475} Formulations containing orphenadrine have been used in the treatment of acute painful musculoskeletal conditions, including muscle spasms.  

 

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SKU: 26391 - 25 mg Category:

Description

A muscarinic acetylcholine receptor antagonist (Kds = 48, 213, 120, 170, and 129 nM for M1-M5 mAChRs, respectively); decreases oxotremorine-induced muscle activity in rabbits at 2-5 mg/kg; an NMDA receptor antagonist (Ki = 6 µM in human postmortem frontal cortex; IC50 = 16.2 µM in cultured superior colliculus neurons)

Formal name: N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-ethanamine, monohydrochloride

Synonyms:  NSC 82357

Molecular weight: 305.8

CAS: 341-69-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Pain Research

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