A flavonoid with diverse biological activities; inhibits poly(I:C)-induced decreases in cell viability and increases in NO production in RAW 264.7 macrophages at 5-25 μM; inhibits poly(I:C)-induced increases in IL-1α

Oroxylin A – 10 mg

Brand:
Cayman
CAS:
480-11-5
Storage:
-20
UN-No:
Non-Hazardous - /

Oroxylin A is a flavonoid that has been found in S. radix and has diverse biological activities.{47464,47465,47466} It inhibits decreases in cell viability and increases in nitric oxide (NO) production induced by polyinosinic-polycytidylic acid (poly(I:C)) in RAW 264.7 macrophages when used at concentrations ranging from 5 to 25 μM.{47465} Oroxylin A (10-50 μM) also inhibits poly(I:C)-induced increases in IL-1α, IL-1β, GM-CSF, IL-6, IL-10, monocyte chemoattractant protein-1 (MCP-1), and TNF-α production in RAW 264.7 cells. Oroxylin A (10 and 20 μM) inhibits hypoxia-induced migration and invasion of MCF-7, DU145, and HepG2 cells in wound healing and cell invasion assays, respectively.{47466} It is an inhibitor of the UDP-glucuronosyltransferase (UGT) isoform UGT1A1 (IC50 = 9.14 μM) and P-glycoprotein (IC50 = 78.3 μM).{47467,47468} Oroxylin A increases the cytotoxicity of the P-glycoprotein substrate paraquat in MDR1-MDCKII cells and paclitaxel (Item No. 10461) in MX-1 and MX-1/T cells.{47468}  

 

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Description

A flavonoid with diverse biological activities; inhibits poly(I:C)-induced decreases in cell viability and increases in NO production in RAW 264.7 macrophages at 5-25 μM; inhibits poly(I:C)-induced increases in IL-1α, IL-1β, GM-CSF, IL-6, IL-10, MCP-1, and TNF-α production in RAW 264.7 cells at 10-50 μM; inhibits hypoxia-induced migration and invasion of MCF-7, DU145, and HepG2 cells in wound healing and cell invasion assays, respectively, at 10 and 20 μM; an inhibitor of UGT1A1 (IC50 = 9.14 μM) and P-glycoprotein (IC50 = 78.3 μM); increases the cytotoxicity of the P-glycoprotein substrate paraquat in MDR1-MDCKII cells and paclitaxel in MX-1 and MX-1/T cells

Formal name: 5,7-dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one

Synonyms:  6-Methoxybaicalein

Molecular weight: 284.3

CAS: 480-11-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Small Molecule Inhibitors||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Toxicology|Drug Metabolism

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