A flavone glycoside with diverse biological activities; scavenges DPPH radicals (IC50 = 316.21 µg/ml); decreases the cytopathic effects of parainfluenza type 3 virus in Hep-2 cells (IC50 = 11.7 µg/ml); inhibits LPS-induced barrier disruption

Orientin – 250 mg

Brand:
Cayman
CAS:
28608-75-5
Storage:
-20
UN-No:
Non-Hazardous - /

Orientin is a flavone glycoside originally isolated from P. orientale that has diverse biological activities, including antioxidant, antibacterial, and anti-inflammatory properties.{36797,36798,36799,36800} Orientin scavenges 2,2-diphenyl-1-picryl-hydrazyl (DPPH; Item No. 14805) radicals with an IC50 value of 316.21 µg/ml.{36798} It also decreases the cytopathic effects of parainfluenza type 3 virus with an IC50 value of 11.7 µg/ml and a cytotoxic concentration (CC50) value of 375 µg/ml in Hep-2 cells.{36799} Orientin (5-40 µM) inhibits LPS-induced barrier disruption, decreases the expression of toll-like receptor 4 (TLR4), phosphorylated p38, and NF-κB, and decreases TNF-α production and IL-6 secretion in a dose-dependent manner in human umbilical vein endothelial cells (HUVECs).{36800} It also prolongs survival in a mouse model of LPS-induced lethal endotoxemia when administered at a dose of 36 µg/animal 12 hours after LPS administration.  

 

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SKU: 25143 - 250 mg Category:

Description

A flavone glycoside with diverse biological activities; scavenges DPPH radicals (IC50 = 316.21 µg/ml); decreases the cytopathic effects of parainfluenza type 3 virus in Hep-2 cells (IC50 = 11.7 µg/ml); inhibits LPS-induced barrier disruption, decreases the expression of TLR4, phosphorylated p38, and NF-κB, and decreases TNF-α production and IL-6 secretion in HUVECs at 5-40 µM; prolongs survival in a mouse model of LPS-induced lethal endotoxemia at 36 µg/animal

Formal name: 2-(3,4-dihydroxyphenyl)-8-β-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 448.4

CAS: 28608-75-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Viral Diseases|Influenza||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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