A 5-HT2C receptor agonist (EC50 = 97.72 nM in a FLIPR-based intracellular calcium assay using CHO-K1 cells expressing the human receptors); selective for 5-HT2C over 5-HT2A and 5-HT2B receptors (EC50s = 419.87 and 524.81 nM

ORG 12962 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
210821-63-9
Storage:
-20
UN-No:
Non-Hazardous - /

ORG 12962 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2C with an EC50 value of 97.72 nM in a FLIPR-based intracellular calcium assay using CHO-K1 cells expressing the human receptor.{52211} It is selective for 5-HT2C over 5-HT2A and 5-HT2B receptors (EC50s = 419.87 and 524.81 nM, respectively). ORG 12962 (1 and 3.2 mg/kg) has anti-aversive effects in a rat model of panic anxiety induced by dorsolateral periaqueductal gray matter (dPAG) stimulation.{48814}  

 

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Description

A 5-HT2C receptor agonist (EC50 = 97.72 nM in a FLIPR-based intracellular calcium assay using CHO-K1 cells expressing the human receptors); selective for 5-HT2C over 5-HT2A and 5-HT2B receptors (EC50s = 419.87 and 524.81 nM, respectively)

Formal name: 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-piperazine, monohydrochloride

Synonyms:  Ro 44-6956

Molecular weight: 302.1

CAS: 210821-63-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety

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