A sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin

Ophiobolin B – 1 mg

Brand:
Cayman
CAS:
5601-74-1
Storage:
-20
UN-No:
Non-Hazardous - /

Calmodulin is a calcium-sensing protein that regulates a wide array of proteins involved in diverse cellular functions. Ophiobolin B is a sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin, producing cytotoxic and antimicrobial effects. It induces apoptosis in chronic lymphocytic leukemia cells with an LC50 value of 2 nM and in different zygomycetes with MIC values ranging from 25-50 µg/ml.{30257,30258}  

 

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Description

A sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin, producing anti-leukemic and antimicrobial effects

Formal name: (1R,3aS,6aR,7S,9aR,10aS)-7-[(1S)-1,5-dimethyl-4-hexen-1-yl]-1,2,3,3a,6,6a,7,8,9,9a,10,10a-dodecahydro-1,7-dihydroxy-1,9a-dimethyl-3-oxo-dicyclopenta[a,d]cyclooctene-4-carboxaldehyde

Synonyms:  Cochliobolin B|Ophiobolsin A|Zizanin B

Molecular weight: 402.6

CAS: 5601-74-1

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death|Apoptosis

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