A metabolite and degradation product of the pesticide DDT; accumulates in various fish and sediment surrounding a DDT manufacturing plant; inhibits estrogen binding to rtERs (IC50 = 3.2 μM); induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles; induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles; increases degeneration of ovarian follicles and reduces testicular size in Japanese medaka (O. latipes)

o,p’-DDE – 5 mg

Brand:
Cayman
CAS:
3424-82-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

o,p’-DDE is a metabolite and degradation product of the organochlorine pesticide DDT.{39801} It accumulates in smallmouth buffalo, channel catfish, and largemouth bass as well as sediment in the Huntsville Spring Branch-Indian Creek tributary system surrounding a DDT manufacturing plant where it is considered a persistent organic pollutant (POP). o,p’-DDE inhibits estrogen binding to rainbow trout estrogen receptors (rtERs) with an IC50 value of 3.2 μM.{12991} It induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles.{39802} In ovo exposure to o,p’-DDE increases degeneration of ovarian follicles and reduces testicular size in Japanese medaka (O. latipes).{39803}  

 

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SKU: 24235 - 5 mg Category:

Description

A metabolite and degradation product of the pesticide DDT; accumulates in various fish and sediment surrounding a DDT manufacturing plant; inhibits estrogen binding to rtERs (IC50 = 3.2 μM); induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles; induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles; increases degeneration of ovarian follicles and reduces testicular size in Japanese medaka (O. latipes),

Formal name: 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethenyl]-benzene

Synonyms:  o,p’-Dichlorodiphenyldichloroethylene|2,4’-DDE|NSC 59908

Molecular weight: 318

CAS: 3424-82-6

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Pesticides||Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Toxicology|Drug Metabolism||Research Area|Toxicology|Environmental|Aquatic Systems||Research Area|Toxicology|Environmental|Endocrine Disruption||Research Area|Toxicology|Environmental|Steroids

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