An orally bioavailable proteasome inhibitor; targets the chymotrypsin-like activity of the 20S proteasome subunits β5 and LMP7 (IC50s = 36 and 82 nM

ONX 0912 – 5 mg

Brand:
Cayman
CAS:
935888-69-0
Storage:
-20
UN-No:
Non-Hazardous - /

ONX 0912 is an orally bioavailable proteasome inhibitor.{28242} It potently targets the chymotrypsin-like activity of the 20S proteasome subunits β5 and LMP7 (IC50s = 36 and 82 nM, respectively).{28242} ONX 0912 inhibits the growth of multiple myeloma cells at nanomolar concentrations while not decreasing the viability of normal peripheral blood mononuclear cells at 1 µM.{28245} It blocks the growth of xenografted human multiple myeloma cells in mice when given orally.{28245} ONX 0912 has potential applications in certain types of cancer as well as other diseases that require proteasome activity.{28240,28241,28243,28244}  

 

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Description

An orally bioavailable proteasome inhibitor; targets the chymotrypsin-like activity of the 20S proteasome subunits β5 and LMP7 (IC50s = 36 and 82 nM, respectively); inhibits the growth of multiple myeloma cells at nanomolar concentrations

Formal name: O-​methyl-​N-​[(2-​methyl-​5-​thiazolyl)​carbonyl]​-​L-​seryl-​O-​methyl-​N-​[(1S)​-​2-​[(2R)​-​2-​methyl-​2-​oxiranyl]​-​2-​oxo-​1-​(phenylmethyl)​ethyl]​-L-​serinamide

Synonyms:  Oprozomib|PR-047

Molecular weight: 532.6

CAS: 935888-69-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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