A potent and selective competitive antagonist of the EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1

ONO-8711 – 10 mg

Brand:
Cayman
CAS:
216158-34-8
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Prostaglandin E2 (PGE2) initiates its cellular effects by activating one of four E prostanoid (EP) receptors, EP1-4. ONO-8711 is a potent and selective competitive antagonist of the EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1, respectively, versus 67 and 76 nM for mouse EP3 and human thromboxane receptor, respectively, and >1,000 nM for other receptors).{7415} ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer.{7415,10246,19682} It also suppresses pain and acid-induced HCO3- secretion in the stomach.{10093,19683,19684}  

 

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Description

A potent and selective competitive antagonist of the EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1, respectively); effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer; suppresses pain and acid-induced HCO3- secretion in the stomach

Formal name: 6-[(2R,3S)-3-[[[(4-chloro-2-methylphenyl)sulfonyl]amino]methyl]bicyclo[2.2.2]oct-2-yl]-5Z-hexenoic acid

Synonyms: 

Molecular weight: 440

CAS: 216158-34-8

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Pain Research

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