A selective

ONO-8130 – 10 mg

Brand:
Cayman
CAS:
459841-96-4
Storage:
-20
UN-No:
Non-Hazardous - /

ONO-8130 is an orally bioavailable antagonist of the prostaglandin E2 (PGE2) receptor EP1 (Ki = 1.9 nM){31234,22585} It exerts a more than 1,000-fold selectivity for EP1 compared with other EP receptors.{22585} ONO-8130 suppresses pain associated with cyclophosphamide-induced cystitis in mice at 0.3-30 mg/kg.{31234} It also blocks PGE2-induced contraction and eliminates spontaneous tone of guinea pig trachea tested in tissue organ baths.{22585}  

 

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Description

A selective, orally bioavailable antagonist of the EP1 receptor (Ki = 1.9 nM); suppresses pain associated with cyclophosphamide-induced cystitis in mice

Formal name: 4-[[[2,3-dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-inden-5-yl]oxy]methyl]-benzoic acid

Synonyms: 

Molecular weight: 500.6

CAS: 459841-96-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Pain Research

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