An analog of ONO-4059

ONO-4059 analog – 10 mg

Brand:
Cayman
CAS:
1351635-67-0
Storage:
-20
UN-No:
Non-Hazardous - /

ONO-4059 analog is the [(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl] analog of the recently published structure of ONO-4059.{31345} ONO-4059 is an orally bioavailable inhibitor of Bruton’s tyrosine kinase (BTK; IC50 = 2.2 nM), a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells.{30641} ONO-4059 reversibly blocks B cell receptor signaling and B cell proliferation and activation.{30641} ONO-4059 suppresses the generation of inflammatory chemokines and cytokines in a mouse model of collagen-induced arthritis, resulting in regression of cartilage erosion, bone damage, and pannus formation.{30641} ONO-4059 is in clinical trials concerning certain leukemias and lymphomas, including chronic lymphocytic leukemia.{30642,30643,31345} The actions of ONO-4059 analog have not been studied.  

 

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Description

An analog of ONO-4059, an orally bioavailable inhibitor of BTK (IC50 = 2.2 nM) that reversibly blocks B cell receptor signaling and B cell proliferation and activation

Formal name: 6-​amino-​7,​9-​dihydro-​9-​[(3S)​-​1-​(1-​oxo-​2-​propen-​1-​yl)​-​3-​piperidinyl]​-​7-​(4-​phenoxyphenyl)​-8H-​purin-​8-​one

Synonyms:  GS-4059 analog

Molecular weight: 456.5

CAS: 1351635-67-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cell Signaling

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