Description
A triterpenoid saponin with neuroprotective activity; inhibits glutamate- or serum-starvation-induced neurotoxicity in PC12 cells at 10 μM; decreases amyloid-β production in HEK293/APPswe cells (IC50 = 10 μM); reduces spatial learning and memory deficits in the Morris water maze in an APP/PS1 transgenic mouse model of Alzheimer’s disease at 10 mg/kg per day; prevents D-galactose-induced decreases in hippocampal GSH levels and increases in hippocampal MDA, IL-1β, IL-6, and TNF-α levels in a rat model of D-galactose-induced aging at 10 and 20 mg/kg
Formal name: (2β,3β,4α)-3-(β-D-glucopyranosyloxy)-2,27-dihydroxy-olean-12-ene-23,28-dioic acid, 28-[O-6-deoxy-α-L-mannopyranosyl-(1→3)-O-[O-β-D-galactopyranosyl-(1→4)-O-β-D-xylopyranosyl-(1→4)-6-deoxy-α-L-mannopyranosyl-(1→2)]-6-deoxy-4-O-[(2E)-3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-galactopyranosyl] ester
Synonyms: (E)-Senegin III
Molecular weight: 1,573.70
CAS: 35906-36-6
Purity: ≥95%
Formulation: A solid
