A selective inhibitor of Hsp90 (IC50 = 18 nM); induces the degradation of specific Hsp90 client proteins; efficacious in a range of xenograft models

Onalespib – 5 mg

Brand:
Cayman
CAS:
912999-49-6
Storage:
-20
UN-No:
Non-Hazardous - /

Onalespib is a selective inhibitor of Hsp90 (IC50 = 18 nM).{18725} It induces the degradation of specific Hsp90 client proteins, including mutant EGFR, for up to seven days in tumor cell lines in vitro and up to three days in vivo.{18725,33082} Onalespib is retained in tumor xenografts and is efficacious in a range of xenograft models.{33082}  

 

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SKU: 10655 - 5 mg Category:

Description

A selective inhibitor of Hsp90 (IC50 = 18 nM); induces the degradation of specific Hsp90 client proteins; efficacious in a range of xenograft models

Formal name: [1,3-dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]-methanone

Synonyms:  AT-13387

Molecular weight: 409.5

CAS: 912999-49-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer||Research Area|Cell Biology|Cellular Chaperones

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