The major metabolite of the gastric proton pump inhibitor

Omeprazole sulfone – 50 mg

Brand:
Cayman
CAS:
88546-55-8
Storage:
-20
UN-No:
Non-Hazardous - /

Omeprazole sulfone is the major metabolite of the gastric proton pump inhibitor, omeprazole (Item No. 14880). It is produced by cytochrome P450 (CYP)3A4 sulfoxidation of esomeprazole (Item No. 17326) and is found in plasma.{30673} Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 18 µM).{30672}  

 

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Description

The major metabolite of the gastric proton pump inhibitor, omeprazole; produced by CYP3A4 sulfoxidation of esomeprazole

Formal name: 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole

Synonyms: 

Molecular weight: 361.4

CAS: 88546-55-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Transporter & Exchanger Modulators||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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