A selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 1.1 μM); racemic mixture of the prodrugs S-omeprazole (esomeprazole) and R-omeprazole

Omeprazole – 500 mg

Brand:
Cayman
CAS:
73590-58-6
Storage:
-20
UN-No:
Non-Hazardous - /

Omeprazole is a selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 1.1 μM).{14045} It is a racemic mixture of two enantiomers, (S)-omeprazole (esomeprazole; Item No. 17326) and (R)-omeprazole (Item No. 18874), which are prodrugs of the active sulfonamide formed by acid-stimulated conversion.{18256,18249} Both enantiomers are extensively metabolized by the cytochrome P450 (CYP) isomers CYP2C19 and CYP3A4.{18249}  

 

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Description

A selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 1.1 μM); racemic mixture of the prodrugs S-omeprazole (esomeprazole) and R-omeprazole

Formal name: 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

Synonyms:  OMEP|OMP|OMZ

Molecular weight: 345.4

CAS: 73590-58-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Immunology & Inflammation|Gastric Disease

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