An orally bioavailable and potent inhibitor of HCV NS5A; reduces HCV replication in stable replicon cell lines with EC50 values of 0.82 to 19.3 pM against genotypes 1a

Ombitasvir – 1 mg

Brand:
Cayman
CAS:
1258226-87-7
Storage:
-20
UN-No:
Non-Hazardous - /

Ombitasvir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A).{32953,38818} It reduces HCV replication in stable replicon cell lines with EC50 values ranging from 0.82 to 19.3 pM against genotypes 1a, 1b, 2a, 2b, 3a, 4a, and 5a and an EC50 value of 366 pM for genotype 6a.{32953,38818} Against subgenomic replicons from clinical isolates of genotypes 1a-6a expressed in Huh-7 derived cells, ombitasvir inhibits HCV replication with EC50 values ranging from 0.1 pM for genotype 4a to 68 pM for genotype 6a.{38818} Formulations containing ombitasvir have been used in the treatment of HCV genotypes 1 and 4.  

 

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SKU: 24116 - 1 mg Category:

Description

An orally bioavailable and potent inhibitor of HCV NS5A; reduces HCV replication in stable replicon cell lines with EC50 values of 0.82 to 19.3 pM against genotypes 1a, 1b, 2a, 2b, 3a, 4a, and 5a and an EC50 value of 366 pM for genotype 6a; inhibits HCV replication against subgenomic replicons of clinical isolates of genotype 1a to 6a (EC50s = 0.1 to 68 pM) ,

Formal name: 2,2′-[[(2S,5S)-1-[4-(1,1-dimethylethyl)phenyl]-2,5-pyrrolidinediyl]di-4,1-phenylene]bis[N-(methoxycarbonyl)-L-valyl-L-prolinamide

Synonyms:  ABT-267

Molecular weight: 894.1

CAS: 1258226-87-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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