A prodrug form of 5-ASA; increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50 = 0.3 mM); stimulates fluid transport in rat jejunum (5 mM); improves stool consistency and decreases occult and gross bleeding as well as MPO activity and LTB4 levels in colon tissue in a mouse model of dextran sulfate-induced colitis (150 mg/kg for 8 days); inhibits bovine xanthine oxidase in vitro (IC50 = 3.4 mg/L); lowers serum uric acid levels in an oxonic acid-induced mouse model of hyperuricemia (20 mg/kg)

Olsalazine (sodium salt) – 5 g

Brand:
Cayman
CAS:
6054-98-4
Storage:
-20
UN-No:
Non-Hazardous - /

Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (5-ASA; Item No. 70265) that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.{30379} In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50 = 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of 5 mM.{41622,41623} Olsalazine (150 mg/kg for 8 days) improves stool consistency and decreases occult and gross bleeding as well as myeloperoxidase (MPO) activity and leukotriene B4 (LTB4; Item No. 20110) levels in colon tissue in a mouse model of acute colitis induced by dextran sulfate (Item No. 23250).{41624} Olsalazine also inhibits bovine xanthine oxidase in vitro (IC50 = 3.4 mg/L) and lowers serum uric acid levels in a mouse model of hyperuricemia induced by oxonic acid (Item No. 22586) when administered at a dose of 20 mg/kg.{41625} Formulations containing olsalazine have been used in the treatment of inflammatory bowel disease (IBD) and ulcerative colitis.  

 

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Description

A prodrug form of 5-ASA; increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50 = 0.3 mM); stimulates fluid transport in rat jejunum (5 mM); improves stool consistency and decreases occult and gross bleeding as well as MPO activity and LTB4 levels in colon tissue in a mouse model of dextran sulfate-induced colitis (150 mg/kg for 8 days); inhibits bovine xanthine oxidase in vitro (IC50 = 3.4 mg/L); lowers serum uric acid levels in an oxonic acid-induced mouse model of hyperuricemia (20 mg/kg)

Formal name: 3,3′-(1,2-diazenediyl)bis[6-hydroxy-benzoic acid, disodium salt

Synonyms:  C.I. 14130

Molecular weight: 346.2

CAS: 6054-98-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes

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