A monounsaturated fatty acid; a major component of membrane phospholipids; inhibits collagen-stimulated platelet aggregation at 10 µg/ml; inhibits fMLF-induced neutrophil aggregation and degranulation at 5 µM; induces release of intracellular calcium in human platelets at 60 µM; increases TNF-α

Oleic Acid (sodium salt) – 50 g

Brand:
Cayman
CAS:
143-19-1
Storage:
-20
UN-No:
Non-Hazardous - /

Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue.{3964,42296} It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.{3964} Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 µg/ml. It also inhibits fMLF-induced neutrophil aggregation and degranulation by 55 and 68%, respectively, when used at a concentration of 5 µM, similar to arachidonic acid (Item No. 90010 | 90010.1 | 10006607).{2095} Oleic acid (60 µM) induces release of intracellular calcium in human platelets.{4198} In vivo, oleic acid increases TNF-α, IL-8, IL-6, and IL-1β production, neutrophil accumulation, and apoptotic and necrotic cell death in mouse lung and has been used to induce lung injury in a mouse model of acute respiratory distress syndrome (ARDS).{42296}  

 

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Description

A monounsaturated fatty acid; a major component of membrane phospholipids; inhibits collagen-stimulated platelet aggregation at 10 µg/ml; inhibits fMLF-induced neutrophil aggregation and degranulation at 5 µM; induces release of intracellular calcium in human platelets at 60 µM; increases TNF-α, IL-8, IL-6, and IL-1β production, neutrophil accumulation, and apoptotic and necrotic cell death in mouse lung,

Formal name: 9Z-octadecenoic acid, monosodium salt

Synonyms:  cis-9-Octadecenoic Acid|Sodium Oleate

Molecular weight: 304.4

CAS: 143-19-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Fatty Acids||Product Type|Biochemicals|Lipids|Octadecanoids||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases||Research Area|Lipid Biochemistry|Fatty Acids

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