An agonist of 5-HT1A and a derivative of oleanolic acid; acts as an agonist at the 5-HT1A receptor in mouse hippocampal homogenates in a [35S]GTPγS binding assay (EC50 = 0.79 µM); a selective inhibitor of MAO-A over MAO-B (IC50s = 48.8 µM and >100 µM

Oleanolic Acid Acrylate – 1 mg

Brand:
Cayman
CAS:
1975976-24-9
Storage:
-20
UN-No:
Non-Hazardous - /

Oleanolic acid acrylate (OAA) is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A and a derivative of oleanolic acid (Item No. 11726).{50366} It acts as an agonist at the 5-HT1A receptor in mouse hippocampal homogenates in a [35S]GTPγS binding assay (EC50 = 0.79 µM). It is also a selective inhibitor of MAO-A over MAO-B (IC50s = 48.8 µM and >100 µM, respectively). In mice, OAA (10 mg/kg) reduces immobility in the forced swim test and increases the number of crossings and time spent at the center in the open field test, indicating anti-depressant-like and anxiolytic activities.  

 

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SKU: 27206 - 1 mg Category:

Description

An agonist of 5-HT1A and a derivative of oleanolic acid; acts as an agonist at the 5-HT1A receptor in mouse hippocampal homogenates in a [35S]GTPγS binding assay (EC50 = 0.79 µM); a selective inhibitor of MAO-A over MAO-B (IC50s = 48.8 µM and >100 µM, respectively); reduces immobility in the forced swim test and increases the number of crossings and time spent at the center in the open field test, indicating anti-depressant-like and anxiolytic activities in mice at 10 mg/kg

Formal name: 3β-[(1-oxo-2-propen-1-yl)oxy]-olean-12-en-28-oic acid

Synonyms:  OAA

Molecular weight: 510.7

CAS: 1975976-24-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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