Description
A glycoside with diverse biological activities; inhibits NF-κB activation-induced by hydrogen peroxide, LPS, okadaic acid, ceramide, or TNF in U937 cells at 1 µg/ml; inhibits TGEV replication without inducing cytotoxicity in swine testis cells (IC50 = 147 nM); reduces OGD-induced pyramidal neuron cell death in cultured rat brain explant slices; reduces viability and inhibits migration of U87MG, A172, U251, and GBM19 glioma cells; reduces tumor size and increases survival in U78MG, GL261, and U251 glioma mouse xenograft models at 0.3 mg/kg
Formal name: (3β,5β,16β)-16-(acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-14-hydroxy-card-20(22)-enolide
Synonyms: Folinerin|Neriolin
Molecular weight: 576.7
CAS: 465-16-7
Purity: ≥98%
Formulation: A solid
