A glycoside with diverse biological activities; inhibits NF-κB activation-induced by hydrogen peroxide

Oleandrin – 1 mg

Brand:
Cayman
CAS:
465-16-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Oleandrin is a glycoside that has been found in N. oleander and has diverse biological activities.{48914,48915,48916,48917} It inhibits NF-κB activation induced by hydrogen peroxide, LPS, okadaic acid (Item No. 10011490), ceramide, or TNF in U937 cells when used at a concentration of 1 µg/ml.{48914} Oleandrin inhibits transmissible gastroenteritis virus (TGEV) replication without inducing cytotoxicity in swine testis cells (IC50 = 147 nM).{48915} It reduces pyramidal neuron cell death induced by oxygen-glucose deprivation (OGD) in cultured rat brain explant slices.{48916} Oleandrin reduces viability and inhibits migration of U87MG, A172, U251, and GBM19 glioma cells.{48917} In vivo, oleandrin (0.3 mg/kg) reduces tumor size and increases survival in U78MG, GL261, and U251 glioma mouse xenograft models.  

 

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SKU: 29871 - 1 mg Category:

Description

A glycoside with diverse biological activities; inhibits NF-κB activation-induced by hydrogen peroxide, LPS, okadaic acid, ceramide, or TNF in U937 cells at 1 µg/ml; inhibits TGEV replication without inducing cytotoxicity in swine testis cells (IC50 = 147 nM); reduces OGD-induced pyramidal neuron cell death in cultured rat brain explant slices; reduces viability and inhibits migration of U87MG, A172, U251, and GBM19 glioma cells; reduces tumor size and increases survival in U78MG, GL261, and U251 glioma mouse xenograft models at 0.3 mg/kg

Formal name: (3β,5β,16β)-16-(acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-14-hydroxy-card-20(22)-enolide

Synonyms:  Folinerin|Neriolin

Molecular weight: 576.7

CAS: 465-16-7

Purity: ≥98%

Formulation: A solid

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