A potent inhibitor of certain serine/threonine protein phosphatases

Okadaic Acid – 25 µg

Brand:
Cayman
CAS:
78111-17-8
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM).{21676,21677,21678} It is a very weak inhibitor of PP2B (IC50 > 2 μM) and does not inhibit PP2C or other phosphatases.{21676,21678} Presumably through these actions, okadaic acid is a potent carcinogen and induces tau phosphorylation.{21680,21681} In sponge, okadaic acid plays a role in defense, inducing apoptosis in symbiotic or parasitic annelids.{21679}  

 

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SKU: 10011490 - 25 µg Category:

Description

A potent inhibitor of certain serine/threonine protein phosphatases, targeting the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM); a very weak inhibitor of PP2B (IC50 > 2 μM); does not inhibit PP2C or other phosphatases

Formal name: (6R)-αR,5R-dihydroxy-a,10-dimethyl-8S-[(2E)-1R-methyl-3-[(2R,4’aR,8’aS)-octahydro-8’R-hydroxy-6’S-[1S-hydroxy-3S-[(6S)-3R-methyl-1,7-dioxaspiro[5.5]undec-2S-yl]butyl]-7′-methylenespiro[furan-2(3H),2′(3’H)-pyrano[3,2-b]pyran]-5R-yl]-2S-propen-1-yl]-1,7-dioxaspiro[5.5]undec-10-ene-2S-propanoic acid

Synonyms:  35-demethyl DTX1|Acanthifolicin|NSC 677083|OA

Molecular weight: 805

CAS: 78111-17-8

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Product Type|Biochemicals|Toxins||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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