A potent inhibitor of LSD1 (IC50 = 0.02 µM) that less effectively inhibits MAO-A and MAO-B (IC50s = 1.38 and 0.72 µM); blocks the expression of IE genes of HSV and hCMV in mammalian cells; represses HSV primary infection in mice and blocks HSV reactivation from latency in a mouse ganglion explant model

OG-L002 – 5 mg

Brand:
Cayman
CAS:
1357302-64-7
Storage:
-20
UN-No:
Non-Hazardous - /

Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression.{14724} Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection.{28724} Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression.{14724} Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection.{28724} OG-L002 is a potent inhibitor of LSD1 (IC50 = 0.02 µM) that less effectively inhibits the monoamine oxidases A (MAO-A) and MAO-B (IC50s = 1.38 and 0.72 µM).{28724} It blocks the expression of immediate early (IE) genes of herpes simplex virus (HSV) in HeLa cells but not that of cellular control genes.{28724} OG-L002 also reduces the expression of human cytomegalovirus IE genes and adenovirus E1A gene in mammalian cells.{28724} It is effective in vivo, repressing HSV primary infection in mice and blocking HSV reactivation from latency in a mouse ganglion explant model.{28724}  

 

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Description

A potent inhibitor of LSD1 (IC50 = 0.02 µM) that less effectively inhibits MAO-A and MAO-B (IC50s = 1.38 and 0.72 µM); blocks the expression of IE genes of HSV and hCMV in mammalian cells; represses HSV primary infection in mice and blocks HSV reactivation from latency in a mouse ganglion explant model

Formal name: 4′-[(1R,2S)-2-aminocyclopropyl]-[1,1′-biphenyl]-3-ol

Synonyms: 

Molecular weight: 225.3

CAS: 1357302-64-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV

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