A chemical probe for the bromodomains of the BRPF family of proteins; binds BRPF1B

OF-1 – 1 mg

Brand:
Cayman
CAS:
919973-83-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

OF-1 is a chemical probe for the bromodomains of the Bromodomain and PHD Finger-containing (BRPF) family of proteins. It binds BRPF1B, BRPF2, and BRPF3 with Kd values of 0.1, 0.5, and 2.4 µM, respectively, as determined by isothermal titration calorimetry. OF-1 increases thermal stability of full length BRPF1B at 1 µM, in the cellular thermal shift assay. It also demonstrates accelerated fluorescence recovery after photobleaching (FRAP) at 5 µM in the BRPF2 FRAP assay. OF-1 shows modest general cytotoxicity. See the Structural Genomics Consortium (SGC) website for further information.  

 

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Description

A chemical probe for the bromodomains of the BRPF family of proteins; binds BRPF1B, BRPF2, and BRPF3 with Kd values of 0.1, 0.,5 and 2.4 µM, respectively, as determined by ITC,

Formal name: 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide

Synonyms: 

Molecular weight: 440.3

CAS: 919973-83-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area|Epigenetics, Transcription, & Translation|Readers|Bromodomains

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