A stable

Octyl-α-ketoglutarate – 10 mg

Brand:
Cayman
CAS:
876150-14-0
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Hypoxia-inducible factor 1α (HIF-1α) turnover is initiated by prolyl hydroxylases (PHD), which hydroxylate proline residues on HIF-1α, facilitating ubiquitination. PHD activity is linked to the tricarboxylic acid (TCA) cycle, since the intermediate α-ketoglutarate is a PHD substrate and succinate and fumarate inhibit PHD. Mutations in enzymes associated with the TCA cycle occur in certain cancers.{21411} Octyl-α-ketoglutarate is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly and preferentially in cells with a dysfunctional TCA cycle.{21289} When used at 1 mM, it stimulates PHD activity, increasing HIF-1α turnover.{21289,21410} In addition, octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD.{21289}  

 

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SKU: 11970 - 10 mg Category:

Description

A stable, cell-permeable form of α-ketoglutarate which accumulates rapidly and preferentially in cells with a dysfunctional TCA cycle; stimulates PHD activity and increases HIF-1α turnover when used at 1 mM; competitively blocks succinate- or fumarate-mediated inhibition of PHD

Formal name: 2-oxo-pentanedioic acid, 1-octyl ester

Synonyms:  α-KG octyl ester

Molecular weight: 258.3

CAS: 876150-14-0

Purity: ≥95%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Fatty Esters/Ethers||Research Area|Cancer|Metabolism||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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