An antagonist of Bcl-2 family members containing four Bcl-2 homology domains

Obatoclax (mesylate) – 50 mg

Brand:
Cayman
CAS:
803712-79-0
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM).{24297} It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.{24296,16717} Obstoclax also induces autophagy in mouse embryo fibroblasts and in HeLa cells.{24298} This compound inhibits the growth of cancer cell lines and primary cancer isolates.{16717,24296}  

 

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SKU: 11499 - 50 mg Category:

Description

An antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd ~500 nM); prevents interaction of these pro-survival proteins with Bax or Bak, inducing apoptosis; also induces autophagy in mouse embryo fibroblasts and in HeLa cell

Formal name: 2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole, monomethanesulfonate

Synonyms:  GX15-070

Molecular weight: 413.5

CAS: 803712-79-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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