An ester of pyruvate and salicylic acid that has neuroprotective properties; decreases LDH release and prevents cell death induced by NMDA or zinc

OBA-09 – 10 mg

Brand:
Cayman
CAS:
856095-68-6
Storage:
-20
UN-No:
Non-Hazardous - /

OBA-09 is an ester of pyruvate and salicylic acid that has neuroprotective properties.{45395} It decreases lactate dehydrogenase (LDH) release and prevents cell death induced by NMDA or zinc, and reduces the production of reactive oxygen species (ROS) induced by oxygen-glucose deprivation in mixed rat primary cortical cells when used at concentrations of 10 and 15 mM. OBA-09 (10 mg/kg) reduces infarct volume by 89.9% and decreases expression of IL-1β, inducible nitric oxide synthase (iNOS), COX-2, and TNF-α in the brain in a rat model of ischemia induced by middle cerebral artery occlusion (MCAO).{45395,45396} It improves motor performance in the rotarod test in the same model when administered at a dose of 10 mg/kg.{45395}  

 

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Description

An ester of pyruvate and salicylic acid that has neuroprotective properties; decreases LDH release and prevents cell death induced by NMDA or zinc, and reduces the production of ROS induced by oxygen-glucose deprivation in mixed rat primary cortical cells when used at concentrations of 10 and 15 mM; reduces infarct volume by 89.9% and decreases expression of IL-1β, iNOS, COX-2, and TNF-α in the brain in a rat model of ischemia induced by MCAO at 10 mg/kg; improves motor performance in the rotarod test in the same model when administered at a dose of 10 mg/kg

Formal name: 2-(1,2-dioxopropoxy)-benzoic acid

Synonyms: 

Molecular weight: 208.2

CAS: 856095-68-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation||Research Area|Neuroscience||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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