Selective inhibitor of monoacylglycerol hydrolysis; blocks 2-oleoyl glycerol hydrolysis in the cytosolic (IC50 = 4.5 µM) and membrane (IC50 = 19 µM) fractions of rat cerebella

O-Arachidonoyl Glycidol – 5 mg

Brand:
Cayman
CAS:
439146-24-4
Storage:
-20
UN-No:
De Minimis - 1231 / 3

2-Arachidonoyl glycerol (2-AG) is an endogenous ligand that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors and is involved in the regulation of a broad range of neurotransmitter signalling functions with implications in neurodegenerative diseases, pain, cancer, and obesity.{15051} Levels of this endocannabinoid are regulated by hydrolysis to glycerol and arachidonic acid by the enzyme monoacylglycerol lipase. O-Arachidonoyl glycidol is a 2-arachidonoyl glycerol analog that blocks 2-oleoyl glycerol hydrolysis in the cytosolic and membrane fractions of rat cerebella with IC50 values of 4.5 and 19 µM, respectively.{15051} O-Arachidonoyl glycidol inhibits fatty acid amide hydrolase-catalyzed hydrolysis of arachidonoyl ethanolamide in the membrane fraction of rat cerebella with an IC50 value of 12 µM.{15051}  

 

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SKU: 10010547 - 5 mg Category:

Description

Selective inhibitor of monoacylglycerol hydrolysis; blocks 2-oleoyl glycerol hydrolysis in the cytosolic (IC50 = 4.5 µM) and membrane (IC50 = 19 µM) fractions of rat cerebella

Formal name: 5Z,8Z,11Z,14Z-eicosatetraenoic acid, oxiranylmethyl ester

Synonyms: 

Molecular weight: 360.5

CAS: 439146-24-4

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Fatty Esters/Ethers||Product Type|Biochemicals|Lipids|Glycerolipids||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Lipid Biochemistry|Glycerolipids||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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