O-ASHA is an irreversible

O-Acetyl Salicylhydroxamic Acid – 10 mg

Brand:
Cayman
CAS:
199854-00-7
Storage:
-20
UN-No:
De Minimis - 3077 / 9

O-Acetyl Salicylhydroxamic Acid (O-ASHA) is an irreversible, non-selective inhibitor of COX-1 and COX-2. Aspirin is the best-studied example of an irreversible COX inhibitor, acting via the acetylation of the active site serine residue 529 in human COX-1. O-ASHA inhibits ovine COX-1 in a time-dependent, irreversible manner with a 50% B/B0 value of approximately 4.5 mM.{9607}  

 

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SKU: 70263 - 10 mg Category:

Description

O-ASHA is an irreversible, non-selective inhibitor of COX-1 and COX-2. Aspirin is the best-studied example of an irreversible COX inhibitor, acting via the acetylation of the active site serine residue 529 in human COX-1. O-ASHA inhibits ovine COX-1 in a time-dependent, irreversible manner with a 50% B/B0 value of approximately 4.5 mM.{9607}

Formal name: N-(acetyloxy)-2-hydroxy benzamide

Synonyms:  AcSHA|O-ASHA

Molecular weight: 195.2

CAS: 199854-00-7

Purity: ≥98%

Formulation: A crystalline solid

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