A selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM); 0-12 mg/kg

O-7460 – 500 µg

Brand:
Cayman
CAS:
1572051-31-0
Storage:
-20
UN-No:
De Minimis - 1231 / 3

In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG; Item No. 62160) by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM).{21752} It demonstrates much weaker inhibition towards human monoacylglycerol lipase and rat brain fatty acid amide hydrolase (IC50s > 10 µM) and does not bind to CB1 or CB2 cannabinoid receptors (Kis > 10 µM).{21752} At 0-12 mg/kg, i.p. in mice, O-7460 was reported to dose-dependently inhibit high-fat diet intake and reduce body weight.{21752}  

 

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Description

A selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM); 0-12 mg/kg, i.p. in mice dose-dependently inhibits high-fat diet intake and reduces body weight

Formal name: 2-[(fluoromethylphosphinyl)oxy]-1-[(1-methylethoxy)methyl]ethyl ester, 9Z-octadecenoic acid

Synonyms: 

Molecular weight: 478.6

CAS: 1572051-31-0

Purity: ≥95%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Small Molecule Inhibitors|Glycerolipid Lipases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Lipid Biochemistry|Glycerolipids|Lipases||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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