A pan-activator of AMPK; increases levels of pAMPK without reducing cellular ATP; suppresses PP2C-mediated dephosphorylation of AMPKα

O-304 – 10 mg

Brand:
Cayman
CAS:
1261289-04-6
Storage:
-20
UN-No:
Non-Hazardous - /

O-304 is a pan-activator of AMP-activated protein kinase (AMPK).{48264} It increases levels of phosphorylated AMPK (pAMPK) without reducing cellular ATP. O-304 suppresses dephosphorylation of AMPKα, AMPKβ, and AMPKγ trimers at threonine 172 (T172) mediated by protein phosphatase 2C (PP2C) without inhibiting PP2C activity in Wi-38 lung fibroblasts. In vivo, O-304 (100 mg/kg) prevents high-fat diet-induced increases in fasted glucose and plasma insulin levels and development of insulin resistance, as well as increases calf muscle pAMPK levels in mice.  

 

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SKU: 26186 - 10 mg Category:

Description

A pan-activator of AMPK; increases levels of pAMPK without reducing cellular ATP; suppresses PP2C-mediated dephosphorylation of AMPKα, AMPKβ, and AMPKγ trimers without inhibiting PP2C activity in Wi-38 lung fibroblasts; prevents high-fat diet-induced increases in fasted glucose and plasma insulin levels and development of insulin resistance, as well as increases calf muscle pAMPK levels in mice at 100 mg/kg

Formal name: 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]-benzamide

Synonyms: 

Molecular weight: 380.2

CAS: 1261289-04-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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