A nitrone free radical spin trap with neuroprotective properties; inhibits transport of tPA from the luminal to the abluminal compartment in an in vitro BBB model under ischemic conditions at 250 μM; decreases infarct volume by 59% in a rat model of transient ischemia induced by MCA occlusion at 10 mg/kg per hour; decreases functional disability in the hemiparetic arm of marmosets in the Hill-and-Valley staircase

NXY-059 – 5 mg

Brand:
Cayman
CAS:
168021-79-2
Storage:
-20
UN-No:
Non-Hazardous - /

NXY-059 is a nitrone free radical spin trap with neuroprotective properties.{37428,37429,37430} It inhibits transport of tissue plasminogen activator (tPA) from the luminal to the abluminal compartment in an in vitro model of the blood-brain barrier (BBB) under ischemic conditions at a concentration of 250 μM.{37431} NXY-059 (10 mg/kg per h) decreases infarct volume by 59% in a rat model of transient ischemia induced by occlusion of the middle cerebral artery (MCA).{37429} It decreases functional disability in the hemiparetic arm of marmosets in the Hill-and-Valley staircase, two-tube choice, and six-tube search tests following MCA occlusion-induced ischemia when administered at a dose of 16 mg/kg per hour.{37430}  

 

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Description

A nitrone free radical spin trap with neuroprotective properties; inhibits transport of tPA from the luminal to the abluminal compartment in an in vitro BBB model under ischemic conditions at 250 μM; decreases infarct volume by 59% in a rat model of transient ischemia induced by MCA occlusion at 10 mg/kg per hour; decreases functional disability in the hemiparetic arm of marmosets in the Hill-and-Valley staircase, two-tube choice, and six-tube search tests following MCA occlusion-induced ischemia at 16 mg/kg per hour

Formal name: 4-[[(1,1-dimethylethyl)oxidoimino]methyl]-1,3-benzenedisulfonic acid, disodium salt

Synonyms:  CPI-22|Disufenton Sodium

Molecular weight: 381.3

CAS: 168021-79-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Spin Traps||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Serum Proteins||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Neuroscience|Neuroprotection|Ischemia

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