A potent and selective inhibitor of CECR2 (IC50 = 0.047 µM by Alpha screen

NVS-CECR2-1 – 10 mg

Brand:
Cayman
CAS:
1992047-61-6
Storage:
-20
UN-No:
Non-Hazardous - /

NVS-CECR2-1 is a potent inhibitor of CECR2 (cat eye syndrome chromosome region, candidate 2), a component of chromatin complexes that regulate gene expression controlling development. It binds CECR2 with high affinity (IC50 = 0.047 µM by Alpha screen, Kd = 0.80 µM by ITC). NVS-CECR2-1 demonstrates no crossreactivity in a panel of 48 bromodomains and has no major activity in kinase, protease, and receptor panels. It shows robust activity in cells by FRAP assay, due to its slow off-rate, and has no acute toxicity. See the Structural Genomics Consortium (SGC) website for more information.  

 

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Description

A potent and selective inhibitor of CECR2 (IC50 = 0.047 µM by Alpha screen, Kd = 0.80 µM by ITC); shows robust activity in cells, by FRAP assay, due to its slow off-rate

Formal name: N-cyclopropyl-2-(propylsulfonyl)-6-[1-(2,2,6,6-tetramethyl-4-piperidinyl)-1H-indol-5-yl]-4-pyrimidinamine

Synonyms:  NVS-1

Molecular weight: 495.7

CAS: 1992047-61-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area|Epigenetics, Transcription, & Translation|Readers

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