A FAK inhibitor (IC50 = 5.5 nM) that also inhibits IGF-1R (IC50 = 0.16 µM); inhibits glioma and ovarian tumor growth in in vivo tumor models

NVP-TAE226 – 5 mg

Brand:
Cayman
CAS:
761437-28-9
Storage:
-20
UN-No:
Non-Hazardous - /

NVP-TAE226 is an inhibitor of focal adhesion kinase (FAK; IC50 = 5.5 nM) and the related proline-rich tyrosine kinase 2-β (PYK2β; IC50 = 5 nM).{32642} It can also inhibit the insulin-like growth factor 1 receptor (IC50 = 0.16 µM) as well as the activity of its downstream target genes such as MAPK and Akt.{32642} NVP-TAE226 has been shown to inhibit glioma and ovarian tumor growth in in vivo tumor models.{15631}  

 

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Description

A FAK inhibitor (IC50 = 5.5 nM) that also inhibits IGF-1R (IC50 = 0.16 µM); inhibits glioma and ovarian tumor growth in in vivo tumor models

Formal name: 2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-benzamide

Synonyms:  TAE226

Molecular weight: 468.9

CAS: 761437-28-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IGF-1R/InsR Family||Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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