A selective IGF-1R inhibitor (IC50 = 0.17 µM); inhibits tumor proliferation both in vitro and in a mouse model of multiple myeloma

NVP-ADW742 – 10 mg

Brand:
Cayman
CAS:
475488-23-4
Storage:
-20
UN-No:
Non-Hazardous - /

NVP-ADW742 is an insulin-like growth factor 1 receptor (IGF-1R) inhibitor with an IC50 value of 0.17 µM.{31811} It exhibits 6-fold greater selectivity for IGF-1R over the insulin receptor (InsR) kinase and minimal inhibitory activity against c-Kit, HER1, PDGFR, VEGFR2, or Bcr-Abl p210.{31811} NVP-ADW742 has been shown to inhibit tumor proliferation both in vitro and in a mouse model of multiple myeloma.{31811}  

 

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Description

A selective IGF-1R inhibitor (IC50 = 0.17 µM); inhibits tumor proliferation both in vitro and in a mouse model of multiple myeloma

Formal name: 5-[3-(phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Synonyms:  ADW742|GSK552602A

Molecular weight: 453.6

CAS: 475488-23-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IGF-1R/InsR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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